01Improvement of atopic dermatitis
Subcutaneous administration of adipose stem cell-derived exosomes in a mouse model of atopic dermatitis markedly reduced transepidermal water loss, promoted stratum corneum rehydration, and dose-dependently reduced inflammatory cytokine levels, including IL-4, IL-5, IL-13, TNF-α, IFN-γ, IL-17 and TSLP. The results showed that the levels of inflammatory cytokines such as IL-4, IL-5, IL-13, TNF-α, IFN-γ, IL-17, and TSLP were significantly reduced in a dose-dependent manner.
Electron microscopic analysis showed that the administration of adipose stem cell-derived exosomes enhanced epidermal lamellar bodies, forming a lamellar layer at the interface between the SC and granular layer.
RNA sequencing analysis of skin lesions shows that adipose stem cell-derived exosomes restore expression of genes involved in the skin barrier, lipid metabolism, cell cycle, and inflammatory response.